Comparison of glycosyl donors: a supramer approach

• Anna V. Orlova,
• Nelly N. Malysheva,
• Maria V. Panova,
• Nikita M. Podvalnyy,
• Michael G. Medvedev and
• Leonid O. Kononov

Beilstein J. Org. Chem. 2024, 20, 181–192, doi:10.3762/bjoc.20.18

• the structure of the solution in a discontinuous manner [33][34][35][37][39][46][56][57][58][60]. These abrupt changes (discontinuities) in the solution structure can be revealed by supramer analysis, which relies on the examination of the plots of numerical data that are related to the reaction

• ] (see also the discussion below). In other words, the rational selection of concentrations for performing glycosylation reactions takes into consideration changes in solution structure with concentration. Accordingly, before carrying out the glycosylation experiments, we investigated, similarly to the

• ]. Conversely, the observed differences in SR values of solutions belonging to different concentration ranges are associated with changes in solution structure (see [33][37][39][46][57][60][62][63] for the details). This observation suggests that different types of supramers of each sialyl donor could be

NMRium: Teaching nuclear magnetic resonance spectra interpretation in an online platform

• Luc Patiny,
• Hamed Musallam,
• Alejandro Bolaños,
• Michaël Zasso,
• Julien Wist,
• Metin Karayilan,
• Eva Ziegler,
• Johannes C. Liermann and
• Nils E. Schlörer

Beilstein J. Org. Chem. 2024, 20, 25–31, doi:10.3762/bjoc.20.4

• desired spectra in JCAMP-DX format and a molfile of the solution structure in each exercise folder. The rest of the required steps happens automatically after the user saves the changes (“commit” in Git terminology) and you get links to distribute to the students. NMRium is also designed as a component

Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications

• Nikita Brodyagin,
• Martins Katkevics,
• Venubabu Kotikam,
• Christopher A. Ryan and
• Eriks Rozners

Beilstein J. Org. Chem. 2021, 17, 1641–1688, doi:10.3762/bjoc.17.116

• intercalation, triplex formation, and backbone chirality shifts [44]. A similar P-form helix having a wide and deep major groove and a shallow and narrow minor groove was also observed for an NMR solution structure of a self-complementary PNA–PNA duplex [45]. Taken together, these results confirmed that, while

Comparative ligand structural analytics illustrated on variably glycosylated MUC1 antigen–antibody binding

• Christopher B. Barnett,
• Tharindu Senapathi and
• Kevin J. Naidoo

Beilstein J. Org. Chem. 2020, 16, 2540–2550, doi:10.3762/bjoc.16.206

• able to affect the structural transition and suppresses the formation of amyloid fibril formation [25]. The solution structure of O-glycosylated prion peptide was not shifted significantly, with only minor shifts seen in the vicinity of the glycosylation site. Yet there is a stabilization of the β

Isolation and structure determination of a tetrameric sulfonyl dilithio methandiide in solution based on crystal structure analysis and ⁶Li/¹³C NMR spectroscopic data

• Jürgen Vollhardt,
• Hans Jörg Lindner and
• Hans-Joachim Gais

Beilstein J. Org. Chem. 2020, 16, 2057–2063, doi:10.3762/bjoc.16.172

• in THF solution in fast equilibrium with a further aggregate, which is stable only at low temperatures. Keywords: crystal structure; dilithio sulfonyl methandiide; NMR; solution structure; X-ray analysis; Introduction Functionalized dilithio methandiides I–III (Figure 1) are a fascinating class of

• dynamics were poor solubility and problems to locate the 13C signals of the dianionic C atoms or the detection of only broad ones. Knowledge of the solution structure of dilithio methandiides would be, however, highly desirable in order to obtain a more complete understanding of the reactivity and

• (2a)4·(THF)6 are in the range of those found in the hexamer (2a)6·Li2O·(THF)6 and functionalized dilithio sulfonyl methandiides [40][43]. Solution structure The synthesis of 2a from sulfone 6Li and 13C-labelled 4 with Li2O-free n-BuLi had yielded the methandiide, being readily soluble in THF. 13C and

From steroids to aqueous supramolecular chemistry: an autobiographical career review

• Bruce C. Gibb

Beilstein J. Org. Chem. 2016, 12, 684–701, doi:10.3762/bjoc.12.69

Second generation silver(I)-mediated imidazole base pairs

• Susanne Hensel,
• Nicole Megger,
• Kristina Schweizer and
• Jens Müller

Beilstein J. Org. Chem. 2014, 10, 2139–2144, doi:10.3762/bjoc.10.221

• linearly coordinated silver(I) ion inserted in-between two complementary artificial imidazole nucleosides (Scheme 1, top). The NMR-based solution structure of a DNA duplex with three contiguous imidazole–Ag(I)–imidazole represented the first experimental proof that a B-DNA conformation is compatible with

Design of a novel tryptophan-rich membrane-active antimicrobial peptide from the membrane-proximal region of the HIV glycoprotein, gp41

• Evan F. Haney,
• Leonard T. Nguyen,
• David J. Schibli and
• Hans J. Vogel

Beilstein J. Org. Chem. 2012, 8, 1172–1184, doi:10.3762/bjoc.8.130

• ; NMR solution structure; membrane interactions; peptides structure–function relationship; Introduction Antimicrobial peptides (AMPs) continue to attract significant attention as potential alternatives to conventional antibiotics. A large number of AMP sequences have been reported in the literature

• the gp41 protein is of particular interest, because it contains five Trp residues, is believed to bind at the surface of the viral membrane [11] and plays an important role in fusing the viral membrane to the target cell membrane. The solution structure of the 19-residue peptide (gp41w) bound to

• to the formation of insoluble peptide–lipid complexes. Unfortunately, due to the loss of CD signal in these samples, it is impossible to determine what type of secondary structure is present in these aggregates. NMR solution structure All the gp41w derivatives were examined by nuclear magnetic